Duke University School of Medicine
Department of Radiation Oncology

Making Discoveries To Guide The Design Of Improved Treatment Strategies For Children And Adults With Brain Tumors
The goal of the Reitman Lab is to make discoveries that guide the design of improved treatment strategies for children and adults with brain tumors. We leverage molecular biology techniques, genetically engineered mouse models, and cancer genomic approaches to carry out our work. The Reitman Lab is based in the Department of Radiation Oncology and the team works closely with the faculty and staff in the Preston Robert Tisch Brain Tumor Center at Duke, the Department of Neurosurgery, the Department of Pathology, and the Duke Cancer Institute.
Our laboratory studies how molecular alterations drive tumor heterogeneity and treatment response, with the goal of identifying new therapeutic vulnerabilities. We have a particular interest in pediatric and adult brain tumors. We develop genetically engineered mouse and human model systems to directly test how cancer-associated mutations shape tumor biology and therapy resistance. Using these platforms, we seek to uncover targetable mechanisms and design rational combination therapies, particularly at the intersection of radiation, molecular and immune therapies. We are especially interested in biological liabilities created by cancer mutations that can be exploited therapeutically. More broadly, we aim to leverage insights from cancer biology not only for treatment development but also for unconventional applications such as engineering useful proteins and biological tools inspired by disease mutations.

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